Question Audit runs a closed-loop audit of the research question itself — the decisions that sink most trials before the first patient is enrolled. Pick the NHS Galleri preset and press Audit Trial Question.
1Audit the questionWhat unstated assumptions are embedded? Is this the right question?
2Synthesize prior evidenceWhich trials tried to answer this — and what failed, and why?
3Analyze the populationWho is the right patient population? What PPV should we expect?
4Generate a trial designEndpoints, eligibility, control arm, statistics, sample-size signal.
5Adversarially critiqueName the top failure modes and the mechanism behind each.
6Produce an adaptive revisionAddress the critique with an enrichment or adaptive design.